S100A2 Protein, Human, Recombinant

S100A2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11 kDa and the accession number is P29034.

S100A2 Protein, Human, Recombinant

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 161,000

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説明	S100A2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11 kDa and the accession number is P29034.

Species	Human
Expression Host	E. coli
Tag	Tag Free
Accession Number	P29034
別名	S100L, CAN19, S100 calcium binding protein A2
Construction	Human S100A2 (NP_005969.1) (Met 2-Pro 98)
Protein Purity	> 95 % as determined by SDS-PAGE
分子量	11 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	The calcium-binding protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21, and S100 proteins consisting of at least 20 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100A2 was first detected in lung and kidney, and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S100A2 protein is a homodimer that undergoes a conformational change upon binding of calcium, and the active form functions in regulating cell proliferation and differentiation, gene transcription, and p53-dependent growth arrest and apoptosis. Accordingly, this protein is regarded as a putative tumor suppressor, and thus chromosomal rearrangements and reduced expression of S100A2 gene have been implicated in certain carcinomas.

参考文献

1. Gimona, M. et al., 1997, J. Cell. Sci. 110: 611-621. 2. Mueller, A. et al., 2005, J. Biol. Chem. 280: 29186-29193. 3. Lapi, E. et al., 2006, Oncogene. 25: 3628-3637. 4. Feng, G. et al., 2001, Cancer. Res. 61: 7999-8004. 5. Gupta, S. et al., 2003, J. Clin. Oncol. 21: 106-112.

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S100A2 Protein, Human, Recombinant

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