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S100A3 Protein, Human, Recombinant (His & MBP)

カタログ番号 TMPY-02222
別名: S100 calcium binding protein A3, S100E

S100A3 Protein, Human, Recombinant (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 55.3 kDa and the accession number is P33764.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
S100A3 Protein, Human, Recombinant (His & MBP)
パッケージサイズ 在庫状況 単価(税別)
100 μg 約5 days ¥ 114,500
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生物学的特性に関する説明
Technical Params
Product Properties
参考文献
説明 S100A3 Protein, Human, Recombinant (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 55.3 kDa and the accession number is P33764.
Species Human
Expression Host E. coli
Tag His, MBP
Accession Number P33764
別名 S100 calcium binding protein A3, S100E
Construction The Human S100A3 (P33764) (Met 1-Gln 101) was fused with an N-terminal polyhistidine-tagged MBP tag at the N-terminus.
Protein Purity > 95 % as determined by SDS-PAGE
分子量 55.3 kDa (predicted)
Endotoxin Please contact us for more information.
Formulation Supplied as sterile PBS, 20% glycerol, pH 7.4.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background Protein S100-A3, also known as Protein S-100E, S100 calcium-binding protein A3, S100A3 and S100E, is a member of the S-100 family. S100A3 / S100E contains 2 EF-hand domains. S100A3 / S100E is highly expressed in the differentiating cuticular cells within the hair follicle and organized into mature hair cuticles. High concentrations of S100A3 homotetramer might provide the millimolar level of Ca2+required for hair cuticular barrier formation. S100A3 / S100E is a unique member of the Ca2+-binding S100 protein family with the highest cysteine content and affinity for Zn2+. S100A3 / S100E binds both calcium and zinc. S100A3 / S100E probably binds 2 zinc ions per molecule. It may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation. S100A3 plays an important role in calcium-dependent processes leading to hair shaft formation. S100A3 / S100E is a unique protein among all members of the calcium-binding S100 family, is specifically expressed at the inner endocuticle of human hair fibers. Upon hair damage, S100A3 / S100E is released from hair fibers and possibly destabilizes the hair tissue architecture.

参考文献

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Keywords

S100A3 Protein, Human, Recombinant (His & MBP) S100 calcium binding protein A3 S100E recombinant recombinant-proteins proteins protein