S100P Protein, Human, Recombinant

S100P Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 10.4 kDa and the accession number is P25815.

S100P Protein, Human, Recombinant

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 114,500

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説明	S100P Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 10.4 kDa and the accession number is P25815.

Species	Human
Expression Host	E. coli
Tag	Tag Free
Accession Number	P25815
別名	MIG9, S100 calcium binding protein P
Construction	The mature form of Human S100P (P25815) (Met 1-Lys 95) was expressed and purified.
Protein Purity	> 97 % as determined by SDS-PAGE
分子量	10.4 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Protein S100-P, also known as Protein S100-E, S100 calcium-binding protein P, S100P and S100E, is a nucleus and cytoplasm protein that belongs to the S-100 family. S100P / S100E contains twoEF-hand domains. S100P protein regulates calcium signal transduction and mediates cytoskeletal interaction, protein phosphorylation and transcriptional control. S100P / S100E overexpression can upregulate androgen receptor expression and thereby promote prostate cancer progression by increasing cell growth. S100P / S100E may directly confer resistance to chemotherapy. S100P / S100E induction may be considered an important step in the initial stage of lung adenocarcinomas, whereas its downregulation in advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role. S100P / S100E plays a major role in the aggressiveness of pancreatic cancer that is likely mediated by its ability to activate RAGE. Interference with S100P / S100E may provide a novel approach for treatment of pancreatic cancer. S100P / S100E could be considered a potential drug target or a chemosensitization target, and could also serve as a biomarker for aggressive, hormone-refractory and metastatic prostate cancer.

参考文献

1. Arumugam,T. et al., 2005, Clin Cancer Res. 11 (15): 5356-64. 2. Basu,G.D. et al., 2008, Int J Cancer. 123 (2): 330-9. 3. Rehbein,G. et al., 2008,Int J Mol Med. 22 (1): 69-77. 4. Heil,A. et al., 2011, J Biol Chem. 286 (9): 7227-38.

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S100P Protein, Human, Recombinant

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