Serpin A3 Protein, Human, Recombinant (His)

カタログ番号 TMPY-01303

別名: ACT, GIG25, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3, GIG24, SERPINA3, AACT, MGC88254, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 3

SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzyme is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease, and mutations of this gene have been observed in patients with Parkinson disease and chronic obstructive pulmonary disease. Besides, ACT gene polymorphism has been implicated with Alzheimer’s disease (AD), cerebral amyloid angiopathy (CAA), as well as stroke, since SerpinA3 is a major constituent of the plaques in AD and an inhibitor of amyloid beta peptide degradation.

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Serpin A3 Protein, Human, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 161,000
1 mg	約5 days	￥ 1,049,000

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Product Properties

参考文献

説明

Species	Human
Expression Host	HEK293 Cells
Tag	His
Accession Number	A0A024R6P0
別名	ACT, GIG25, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3, GIG24, SERPINA3, AACT, MGC88254, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 3
Construction	The Human SERPINA3 (NP_001076.2) (Met 1-Ala 423) was expressed, with a C-terminal polyhistidine tag.
Protein Purity	> 97 % as determined by SDS-PAGE
分子量	46.5 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 25 mM HEPES, 0.15M NaCl, pH 7.8. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzyme is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease, and mutations of this gene have been observed in patients with Parkinson disease and chronic obstructive pulmonary disease. Besides, ACT gene polymorphism has been implicated with Alzheimer’s disease (AD), cerebral amyloid angiopathy (CAA), as well as stroke, since SerpinA3 is a major constituent of the plaques in AD and an inhibitor of amyloid beta peptide degradation.

参考文献

1. Nilsson, L.N. et al., 2001, J. Neurosci. 21: 1444-1451. 2. Ikari, Y. et al., 2001, J. Biol. Chem. 276: 11798-11803. 3. Vila, N. et al., 2000, Stroke. 31: 2103-2105 4. Eriksson, S. et al., 1995, Proc. Natl. Acad. Sci. USA. 92: 2313-2317. 5. Skeel, A. et al., 2001, J. Biol. Chem. 276: 21932-21937.

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Keywords

Serpin A3 Protein, Human, Recombinant (His) GIG 25 MGC-88254 ACT GIG-25 MGC 88254 GIG25 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 SERPINA 3 GIG24 SERPINA-3 SERPINA3 GIG 24 AACT GIG-24 MGC88254 serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 3 recombinant recombinant-proteins proteins protein