SIRP alpha Protein, Mouse, Recombinant (MIgG2a)

カタログ番号 TMPJ-01182

別名: SIRP, CD172 Antigen-Like Family Member A, SIRPA, MFR, Signal-Regulatory Protein α-1, CD172a, SHPS1, Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, Signal-Regulatory Protein Alpha-1

SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation.

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SIRP alpha Protein, Mouse, Recombinant (MIgG2a)

パッケージサイズ	在庫状況	単価(税別)
10 μg	約5 days	￥ 27,000
50 μg	約5 days	￥ 71,500
500 μg	約5 days	￥ 436,000
1 mg	約5 days	￥ 626,500

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生物学的特性に関する説明

Technical Params

Product Properties

説明

Species	Mouse
Expression Host	HEK293 Cells
Tag	C-mIgG2a Fc
Accession Number	Q6P6I8
別名	SIRP, CD172 Antigen-Like Family Member A, SIRPA, MFR, Signal-Regulatory Protein α-1, CD172a, SHPS1, Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, Signal-Regulatory Protein Alpha-1
Amino Acid	Lys32-Asn373
Construction	Lys32-Asn373
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	90-120 KDa, reducing conditions

Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation.

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Keywords

SIRP alpha Protein, Mouse, Recombinant (MIgG2a) SIRP SHPS 1 CD172 Antigen-Like Family Member A SIRPA MFR Signal-Regulatory Protein α-1 SHPS-1 CD172a Signal-Regulatory Protein a-1 SHPS1 Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 Signal-Regulatory Protein Alpha-1 recombinant recombinant-proteins proteins protein