SLAMF7 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60-90 KDa and the accession number is Q9NQ25.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 μg | 約5 days | ¥ 13,000 |
50 μg | 約5 days | ¥ 40,000 |
500 μg | 約5 days | ¥ 321,500 |
1 mg | 約5 days | ¥ 480,000 |
説明 | SLAMF7 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60-90 KDa and the accession number is Q9NQ25. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | C-mFc |
Accession Number | Q9NQ25 |
別名 | CD2 Subset 1, CRACC, CD319, CS1, Membrane Protein FOAP-12, SLAMF7, Protein 19A, SLAM Family Member 7, Novel Ly9, CD2-Like Receptor-Activating Cytotoxic Cells |
Amino Acid | Ser23-Met226 |
Construction | Ser23-Met226 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 60-90 KDa (reducing condition) |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins. |
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Please read the User Guide of Recombinant Proteins for more specific information.
SLAMF7 Protein, Human, Recombinant (mFc) CD2 Subset 1 CRACC CD319 CS-1 CS1 CD-319 Membrane Protein FOAP-12 CS 1 SLAMF7 Protein 19A SLAM Family Member 7 CD 319 Novel Ly9 SLAMF 7 SLAMF-7 CD2-Like Receptor-Activating Cytotoxic Cells recombinant recombinant-proteins proteins protein