SLITRK1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 105-115 kDa and the accession number is Q96PX8.
説明 | SLITRK1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 105-115 kDa and the accession number is Q96PX8. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | C-His |
Accession Number | Q96PX8 |
別名 | TTM, FLJ54428, LRRC12, RP11-395N17.1, KIAA0918, SLITRK1, SLIT and NTRK like family member 1, KIAA1910 |
Construction | extracellular domain (Met 1-Ser 616) of Human SLITRK1 (NP_443142.1) |
Protein Purity | > 95 % as determined by SDS-PAGE |
分子量 | The recombinant human SLITRK1 consists of 610 amino acids and predicts a molecular mass of kDa. As a result of glycosylation, the apparent molecular mass of rhSLITRK1 is approximately 105-115 kDa in SDS-PAGE under reducing conditions. |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | SLITRK1 (Slit and Trk-like family member 1) is a integral membrane protein belonging to the SLITRK family consists of at least 6 members (SLITRK1-6). They are named and characterized by the presence of two leucine-rich repeats (LRRs) in the extracellular domain similar to those found in a secreted axonal growth-controlling protein, Slit, as well as a C-terminal domain with homology to Trk neurotrophin tyrosine kinase receptors. Expression of SLITRKs are highly restricted to neural tissues, and are identified as the neuronal components modulating the neurite outgrowth. More specifically, SLITRK1 expression is found in the mature neurons of the cerebrum, thalamus and hippocampus, and induces unipolar neurites in cultured neuronal cells. Human SLITRK1 is a 696 amino acid precursor protein, and one truncating frameshift mutation (448 aa) has been linked to Tourette's syndrome, a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. In addition, all SLITRK genes are differentially expressed in brain tumors, such as astrocytoma, oligodendroglioma, glioblastoma, and are suggested to be useful molecular indicators of brain tumor properties. |
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SLITRK1 Protein, Human, Recombinant (His) KIAA-1910 TTM FLJ54428 LRRC-12 SLITRK-1 LRRC12 FLJ 54428 LRRC 12 RP11-395N17.1 KIAA0918 KIAA 1910 KIAA 0918 SLITRK1 SLIT and NTRK like family member 1 SLITRK 1 KIAA-0918 FLJ-54428 KIAA1910 recombinant recombinant-proteins proteins protein