SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 μg | 約5 days | ¥ 42,500 |
50 μg | 約5 days | ¥ 125,000 |
500 μg | 約5 days | ¥ 436,000 |
1 mg | 約5 days | ¥ 626,500 |
説明 | SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death. |
Species | Human |
Expression Host | E. coli |
Tag | N-GST |
Accession Number | Q15797 |
別名 | hSMAD1, Transforming Growth Factor-Beta-Signaling Protein 1, Transforming Growth Factor-β-Signaling Protein 1, Mothers Against DPP Homolog 1, MADH1, SMAD Family Member 1, BSP1, Mad-Related Protein 1, SMAD 1, JV4-1, BSP-1, SMAD1, Mothers Against Decapentaplegic Homolog 1, MAD Homolog 1, MADR1 |
Amino Acid | Met1-Ser465 |
Construction | Met1-Ser465 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 58-80 KDa (reducing condition) |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 150 mM NaCl, pH 8.0. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death. |
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SMAD1 Protein, Human, Recombinant (GST) hSMAD1 SMAD-1 Transforming Growth Factor-Beta-Signaling Protein 1 MADH 1 BSP 1 Transforming Growth Factor-β-Signaling Protein 1 Mothers Against DPP Homolog 1 MADH-1 MADH1 SMAD Family Member 1 MADR-1 BSP1 Mad-Related Protein 1 SMAD 1 JV4-1 BSP-1 SMAD1 MADR 1 Mothers Against Decapentaplegic Homolog 1 Transforming Growth Factor-b-Signaling Protein 1 MAD Homolog 1 MADR1 recombinant recombinant-proteins proteins protein