ST2/IL-1 RL1 Protein, Human, Recombinant (isoform a, His)

ST2/IL-1 RL1 Protein, Human, Recombinant (isoform a, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.3 kDa and the accession number is Q01638-1.

ST2/IL-1 RL1 Protein, Human, Recombinant (isoform a, His)

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 138,000
1 mg	約5 days	￥ 897,500

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説明	ST2/IL-1 RL1 Protein, Human, Recombinant (isoform a, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.3 kDa and the accession number is Q01638-1.

Species	Human
Expression Host	HEK293 Cells
Tag	C-His
Accession Number	Q01638-1
別名	ST2L, FIT-1, IL‑1 R4, interleukin 1 receptor-like 1, ST2, DER4, IL1RL1, ST2V, T1, IL33R
Construction	The Human IL1RL1 isoform A (NP_057316.3) (Met 1-Ser 328) was expressed, fused with a polyhistidine tag at the C-terminus.
Protein Purity	> 95 % as determined by SDS-PAGE
分子量	36.3 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.

参考文献

1. Savenije OE,et al.(2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6. 2. Li H,et al.(2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.

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ST2/IL-1 RL1 Protein, Human, Recombinant (isoform a, His)

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