Tau Protein, Human, Recombinant (His)

カタログ番号 TMPY-03425

別名: PPND, FTDP-17, MTBT1, DDPAC, MAPTL, MTBT2, microtubule-associated protein tau, PPP1R103, MAPT, MSTD, TAU

MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.

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Tau Protein, Human, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
50 μg	在庫あり	￥ 88,500
100 μg	約5 days	￥ 151,500
200 μg	約5 days	￥ 257,000
500 μg	約5 days	￥ 521,000

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COA DATASHEET SDS

生物学的特性に関する説明

Technical Params

Product Properties

参考文献

生物学的情報

Testing in progress

説明

Species	Human
Expression Host	E. coli
Tag	His
Accession Number	P10636-2
別名	PPND, FTDP-17, MTBT1, DDPAC, MAPTL, MTBT2, microtubule-associated protein tau, PPP1R103, MAPT, MSTD, TAU
Construction	A DNA sequence encoding the mature form of human MAPT (NP_058525.1) (Ala2-Leu352) was expressed with a polyhistide tag at the N-terminus.
Protein Purity	> 85 % as determined by SDS-PAGE
分子量	38.7 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.

参考文献

1. Harada A, et al. (1994) Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 369(6480):488-91. 2. Weingarten MD, et al. (1975) A protein factor essential for microtubule assembly. Proc Natl Acad Sci. 72(5):1858-62. 3. Goedert M, et al. (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron. 3(4): 519-26.

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Keywords

Tau Protein, Human, Recombinant (His) FTDP17 PPND FTDP-17 MTBT-1 MTBT1 PPP1R 103 DDPAC MAPTL PPP1R-103 MTBT2 microtubule-associated protein tau FTDP 17 PPP1R103 MTBT 1 MAPT MTBT 2 MSTD TAU MTBT-2 recombinant recombinant-proteins proteins protein