Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.
パッケージサイズ | 在庫状況 | 単価(税別) |
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10 μg | 在庫あり | ¥ 27,000 |
50 μg | 約5 days | ¥ 80,500 |
500 μg | 約5 days | ¥ 349,000 |
1 mg | 約5 days | ¥ 870,000 |
生物学的情報 |
Immobilized Mouse TGFBR2 -Fc at 10μg/ml (100 μl/well) can bind Mouse/Rat TGF-beta 2*.*: Biotinylated by NHS-biotin prior to testing. The ED50 of Mouse TGFBR2 -Fc is 0.136 ug/ml. (Regularly tested)
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説明 | Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system. |
Species | Mouse,Rat |
Expression Host | HEK293 Cells |
Tag | Tag Free |
Accession Number | P27090 |
別名 | transforming growth factor β-2, BSC-1 cell growth inhibitor, G-TSF, TGF-β-2, TGF-beta2, MGC116892, Polyergin, Cetermin, TGF-β2, TGFB2, TGF-beta-2, transforming growth factor beta-2, Glioblastoma-derived T-cell suppressor factor |
Amino Acid | Ala303-Ser414 |
Construction | Ala303-Ser414 |
Protein Purity |
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
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分子量 | 12 KDa (reducing condition) |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 4 mM HCl. |
Reconstitution | Reconstitute the lyophilized protein in 4mM HCl. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system. |
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Please read the User Guide of Recombinant Proteins for more specific information.
TGF beta 2 Protein, Mouse/Rat, Recombinant MGC-116892 TGFB 2 transforming growth factor b-2 transforming growth factor β-2 BSC-1 cell growth inhibitor TGFB-2 G-TSF TGF-β-2 TGF-beta2 MGC 116892 MGC116892 Polyergin TGF-b-2 Cetermin TGF-β2 TGFB2 TGF-beta-2 transforming growth factor beta-2 Glioblastoma-derived T-cell suppressor factor recombinant recombinant-proteins proteins protein