TGFBR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.2 kDa and the accession number is P37173.
説明 | TGFBR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.2 kDa and the accession number is P37173. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | C-hFc |
Accession Number | P37173 |
別名 | TGFβ-RII, TGFbeta-RII, MFS2, AAT3, transforming growth factor, beta receptor II (70/80kDa), LDS2B, transforming growth factor, β receptor II, LDS2, TAAD2, RIIC, FAA3, LDS1B, TGFR-2 |
Construction | The Human TGFBR2 (NP_003233.4) (Met1-Asp159) was expressed with the Fc region of Human IgG1 at the C-terminus. |
Protein Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. |
分子量 | 42.2 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilized by a network of six intra strand disulfide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity. |
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TGFBR2 Protein, Human, Recombinant (hFc) TGFR2 TGFβ-RII TGFbeta-RII LDS-2 TAAD 2 MFS2 70/80kDa AAT 3 FAA 3 AAT3 MFS 2 transforming growth factor, beta receptor II (70/80kDa) LDS2B LDS 2 TAAD-2 transforming growth factor, β receptor II AAT-3 transforming growth factor, b receptor II TGFR 2 transforming growth factor, beta receptor II LDS2 TAAD2 RIIC MFS-2 TGFb-RII FAA3 LDS1B TGFR-2 FAA-3 recombinant recombinant-proteins proteins protein