TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 μg | 約5 days | ¥ 14,000 |
50 μg | 約5 days | ¥ 42,500 |
500 μg | 約5 days | ¥ 199,500 |
1 mg | 約5 days | ¥ 298,500 |
説明 | TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | C-hFc |
Accession Number | Q02763-1 |
別名 | TEK tyrosine kinase, endothelial, EC 2.7.10, Tie2, hTIE2, p140 TEK, VMCM, soluble TIE2 variant 2, CD202b, soluble TIE2 variant 1, EC 2.7.10.1, CD202b antigen, Tie-2, TEK, angiopoietin-1 receptor, VMCM1 |
Amino Acid | Ala23-Lys745 |
Construction | Ala23-Lys745 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 120-150 KDa (reducing condition) |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Tie-1/Tie (tyrosine kinase with Ig and EGF homology domains 1) and Tie-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Two ligands, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), which bind Tie-2 with high-affinity have been identified. Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects. |
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Please read the User Guide of Recombinant Proteins for more specific information.
TIE2 Protein, Human, Recombinant (hFc) VMCM 1 TEK tyrosine kinase, endothelial EC 2.7.10 Tie2 hTIE2 p140 TEK VMCM soluble TIE2 variant 2 VMCM-1 CD202b soluble TIE2 variant 1 EC 2.7.10.1 CD202b antigen Tie-2 TEK angiopoietin-1 receptor VMCM1 recombinant recombinant-proteins proteins protein