TWEAK/TNFSF12 Protein, Human, Cynomolgus, Recombinant (mFc)

TWEAK/TNFSF12 Protein, Human, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 43.8 kDa and the accession number is F7HGN4.

TWEAK/TNFSF12 Protein, Human, Cynomolgus, Recombinant (mFc)

パッケージサイズ	在庫状況	単価(税別)
50 μg	約5 days	￥ 88,000
500 μg	約5 days	￥ 551,000

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説明	TWEAK/TNFSF12 Protein, Human, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 43.8 kDa and the accession number is F7HGN4.

Species	Human,Cynomolgus
Expression Host	HEK293 Cells
Tag	N-mFc
Accession Number	F7HGN4
別名	tumor necrosis factor (ligand) superfamily, member 12
Construction	The Human / cynomolgus TNFSF12 (F7HGN4) (Ser94-His249) was expressed with the Fc region of Mouse IgG1 at the N-terminus. Human and Cynomolgus TNFSF12 sequences are identical.
Protein Purity	> 95 % as determined by SDS-PAGE
分子量	43.8 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Wiley SR,et al. (2004) TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine Growth Factor Rev. 14(3-4):241-9. 2. Campbell S,et al. (2006) The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity. Front Biosci. 9:2273-84. 3. Lynch CN,et al. (1999) TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 274(13):8455-9.

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TWEAK/TNFSF12 Protein, Human, Cynomolgus, Recombinant (mFc)

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