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T80530 |
Spinoxin
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SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13 |
Potassium Channel
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Spinoxin, a 34-residue peptide neurotoxin extracted from the venom of Heterometrus spinifer, is characterized by four disulfide bridges. It acts as a potent inhibitor of the Kv1.3 potassium channel with an IC 50 value of... |
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T13540 |
Alpha-Amanitin
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α-Amatoxin,α-Amanitin |
Others
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alpha-Amanitin (alpha-Amanitin) is the lethal toxin in Trichoderma viride and acts in vivo via the enterohepatic circulation and transport system. alpha-Amanitin induces cell death and can be used in the synthesis of ADC... |
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T22297 |
Clindamycin hydrochloride monohydrate
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Clindamycin alcoholate |
Antibiotic
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Clindamycin hydrochloride monohydrate (Clindamycin alcoholate) is a protein synthesis inhibitor used orally, capable of diminishing virulence factor expression in Staphylococcus aureus at sub-minimum inhibitory concentra... |
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T76990 |
Suvratoxumab
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Suvratoxumab (MEDI4893) is a high-affinity, long-acting humanized IgG1κ anti-α-toxin monoclonal antibody. It effectively neutralizes α-toxin, a principal virulence factor of S. aureus, enhancing survival and diminishing ... |
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T80066 |
ShK toxin
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Potassium Channel
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ShK toxin, isolated from the Caribbean sea anemone (Stichodactyla helianthus), is an inhibitor of the voltage-dependent potassium channel (Kv1.3 channel). It competes with dendrotoxin I and α-dendrotoxin in binding to ra... |
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T82415 |
Fasciculin-I
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FAS-I |
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Fasciculin-I, a toxin isolated from mamba venom, exerts its toxicity primarily by inhibiting acetylcholinesterase (AChE). Additionally, it impedes the action of α-neurotoxins on nicotinic acetylcholine receptors and neut... |
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T77217 |
Saccharopine hydrochloride
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Others
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Saccharopine hydrochloride (L-Saccharopine hydrochloride), an intermediate in lysine degradation and a mitochondrial toxin, is produced through the conversion of lysine and α-ketoglutarate by lysine-ketoglutarate reducta... |
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T37439 |
C18 Globotriaosylceramide (d18:1/18:0)
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Others
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C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetat... |
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T76973 |
Tosatoxumab
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Tosatoxumab (AR-301; KBSA301), a human immunoglobulin G1 monoclonal antibody, specifically targets and neutralizes S. aureus alpha-toxin (alpha-hemolysin; Hla) by binding to its N-terminal epitope. This interaction block... |
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T80482 |
α-Conotoxin EIIB
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Alpha-conotoxin EIIB |
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Alpha-Conotoxin EIIB is a peptide toxin derived from Conus ermineus that selectively binds to neuronal nicotinic acetylcholine receptors (nAChR) with a dissociation constant (Ki) of 2.2 nM. This compound is utilized in n... |
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T80034 |
Margatoxin TFA
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Potassium Channel
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Margatoxin TFA, an alpha-KTx scorpion toxin isolated from Centruroides margaritatus venom, is a 39-amino-acid peptide that serves as a high-affinity inhibitor of Kv1.3 (Kd = 11.7 pM). It also inhibits Kv1.2 (Kd = 6.4 pM)... |
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T35426 |
β-Defensin-1 (human) (trifluoroacetate salt)
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β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus... |
