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T4647 |
M2I-1
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M2I 1 |
Others
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M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 cri... |
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T8561 |
Apcin
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APC
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Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substr... |
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T64339 |
Apcin A HCL
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APC
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Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to... |
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T1731 |
TAME hydrochloride
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Tos-Arg-OMe HCl,TOS-ARG-OME hydrochloride |
Amino Acids and Derivatives
,
APC
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TAME hydrochloride (Tos-Arg-OMe HCl) is a kind od amino acid derivatives. |
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T10345 |
Apcin-A
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Others
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Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V. |
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T14642 |
Bis-PEG5-acid
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PROTAC Linker 36 |
Others
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Bis-PEG5-acid (PROTAC Linker 36) is a polyethylene glycol (PEG) linker employed for the synthesis of CP5V, a PROTAC that selectively degrades Cdc20[1]. |
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T10875 |
CP5V
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Others
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CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. |
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T6693 |
TAME
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Tosylarginine methyl ester,N-4-Tosyl-L-arginine methyl ester |
APC
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Tosyl-L-Arginine Methyl Ester (TAME (N-4-Tosyl-L-arginine methyl ester)) is an APC inhibitor. |
