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T74465 |
Colibactin
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Colibactin, a complex secondary metabolite synthesized by certain genotoxic Escherichia coli strains in the gut, holds potential for colorectal cancer research [1]. |
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T72817 |
Colibactin 742
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Others
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Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads to G2/M arrest. |
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T74985 |
MRV03-037
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MRV03-037, a selective colibactin-activated peptidase (ClbP) inhibitor, effectively inhibits the genotoxic effects of Colibactin on eukaryotic cells by blocking the production of gut bacterial genotoxins [1]. |
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T81749 |
MRV03-068
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Compound 2 (MRV03-068) is a selective colibactin-activated peptidase (ClbP) inhibitor, preventing the genotoxic effects of colibactin on eukaryotic cells, with potential applications in colorectal cancer research [1]. |
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T81748 |
MRV03-069
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Compound 3 (MRV03-069) is a selective inhibitor of colibactin-activated peptidase (ClbP), effectively impeding colibactin's genotoxic effects on eukaryotic cells, with potential applications in colorectal cancer research... |
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T74986 |
MRV03-070
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MRV03-070, acting as a biosynthetic precursor akin to precolibactin [1], is a colibactin-activating peptidase ClbP inhibitor with an inhibitory concentration (IC 50) value of 69 nM. |
