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ターゲット

Thyroid hormone receptor(THR)

5

阻害剤

カタログ番号	製品名	別名	ターゲット
T0952	Carbimazole	Athyromazole,Carbimazol,Neomercazole	Thyroid hormone receptor(THR)
	Carbimazole (Athyromazole) is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, and can be used in the study of Graves' disease.		Thyroid hormone receptor(THR)
T12192	NCGC00229600		Others , TSH Receptor
	NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously and can be used in Graves' disease studies.		Others , TSH Receptor
T16106	ML224	NCGC00242364,ANTAG3	TSH Receptor
	ML224 (NCGC00242364) is a TSHR antagonist for the treatment of Graves' orbital disease and Graves' hyperthyroidism.		TSH Receptor
T13217	TSHR antagonist S37a		Others
	TSHR antagonist S37a is a selective antagonist of thyrotropin receptor (TSHR), with potential for the treatment of Graves' orbitopathy.		Others
T77043	Iscalimab
	Iscalimab (CFZ-533), a non-depleting IgG1 monoclonal antibody that targets CD40 with a dissociation constant (K D) of 0.3 nM, is utilized in the research of Graves' hyperthyroidism and autoimmune diseases [1] [2] [3].

Compounds

Synonym: Athyromazole,Carbimazol,Neomercazole

Target: Thyroid hormone receptor(THR)

Target: Others, TSH Receptor

Synonym: NCGC00242364,ANTAG3

Target: TSH Receptor

TSHR antagonist S37a

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