cyclase-C | TargetMol

カタログ番号	製品名	別名	ターゲット
T9080	Plecanatide		Guanylate cyclase
	Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.		Guanylate cyclase
T11852	Linaclotide		Guanylate cyclase
	Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.		Guanylate cyclase
T12501	Plecanatide acetate		Others
	Plecanatide acetate is a agonist of guanylate cyclase-C (GC-C) receptor( EC50 of 190 nM in T84 cells), and shows anti-inflammatory activity in models of murine colitis.		Others
T11852L	Linaclotide acetate	MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775
	Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.
T38482	MM 419447
	MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research.
T76274	Dolcanatide
	Dolcanatide, an orally active guanylate cyclase-C (GC-C) agonist, exhibits laxative, anti-nociceptive, and anti-inflammatory properties. It is utilized in research concerning inflammatory bowel disease [1] [2].
T80067	Uroguanylin (human)		Guanylate cyclase
	Uroguanylin (human) serves as a natural ligand for the Guanylyl Cyclase C (GCC) receptor in metastatic colorectal cancer tumors and exhibits anti-tumor effects in an animal model of human colon cancer [1] [2].		Guanylate cyclase
T76363	[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat
	[Tyr22] Calcitonin Gene Related Peptide (22-37), rat, refers to a fragment (amino acids 22-37) of the rat calcitonin gene-related peptide (CGRP) that targets the CGRP receptor and adenylate cyclase. While calcitonin is p...
T76334	Cenderitide
	Cenderitide, a natriuretic peptide (NP) that combines C-type natriuretic peptide (CNP) with the C-terminus of Dendroaspis natriuretic peptide (DNP), serves as a potent agonist of the particulate guanylyl cyclase receptor...

Compounds

Plecanatide

T9080

Synonym:

Target: Guanylate cyclase

Linaclotide

T11852

Synonym:

Target: Guanylate cyclase

Synonym: MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775

Target: Guanylate cyclase

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00910	GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 65-110 KDa and the accession number is P25092.
TMPJ-00911	GUCY2C Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	GUCY2C Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is P25092.
TMPK-00990	GUCY2C Protein, Mouse, Recombinant (His & Avi)	Mouse	HEK293 Cells
	Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio...
TMPK-01279	GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His)	Cynomolgus	HEK293 Cells
	Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio...
TMPK-00856	GUCY2C Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio...
TMPK-01388	GUCY2C Protein, Canine, Recombinant (aa 21-430, His)	Canine	HEK293 Cells
	Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio...
TMPK-00991	GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293 Cells
	Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio...
TMPH-02993	DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc)	Mycobacterium paratuberculosis	E. coli
	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules int...
TMPH-01386	GLP2R Protein, Human, Recombinant (His)	Human	HEK293 Cells
	This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. GLP2R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with...
TMPH-01715	CHRM2 Protein, Human, Recombinant (His)	Human	E. coli
	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ...
TMPH-01378	GIPR Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. GIPR Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C...
TMPH-00632	Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His & Myc)	E. coli	E. coli
	The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression ...
TMPH-02022	RXFP2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3). RXFP2 Pro...
TMPH-00985	NPR3 Protein, Human, Recombinant (His)	Human	E. coli
	Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance...
TMPH-03250	NPR3 Protein, Rat, Recombinant (His & SUMO)	Rat	E. coli
	Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance...
TMPY-02236	PTH1R Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane pr...
TMPK-01456	HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr...
TMPK-01451	HLA-C 03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr...
TMPK-01450	HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr...