midbrain | TargetMol

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Search Results for " midbrain "

ターゲット

阻害剤

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T28368	PF-04859989 HCl	PF 04859989,PF04859989,PF-04859989HCl,PF-04859989	Others
	PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s...		Others
T4297	Flibanserin	BIMT-17BS,Girosa,BIMT-17	Dopamine Receptor , 5-HT Receptor
	Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n...		Dopamine Receptor , 5-HT Receptor
T27936	LY262691	LY 262691,LY-262691
	LY262691, a selective CCKB antagonist, decreases midbrain dopamine unit activity.
T38202	PAQ
	PAQ is a neuroprotective agent. It protects dopaminergic neurons from cell death without inhibiting glial cell proliferation in a rat midbrain culture model of Parkinson's disease when used at a concentration of 10 μM. P...
T73272	VU6019650
	VU6019650 is a potent and selective orthosteric antagonist of M5 mAChR ( IC 50 =36 nM), can be used for opioid use disorder (OUD) relief. VU6019650 can cross blood brain barrier, potentially modulates the mesolimbic dopa...
T62706	RTI-7470-44
	RTI-7470-44 is a potent and selective human trace amine-associated receptor 1 (hTAAR1) antagonist (IC50: 8.4 nM) that crosses the blood-brain barrier. RTI-7470-44 increases the spontaneous firing rate of dopaminergic neu...
T70818	TC-2153
	TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), exhibiting psychotropic activity and low acute toxicity. This compound not only enhances the expression of brain-derived neurotro...
T76404	[Glp5,(Me)Phe8,Sar9] Substance P (5-11)
	[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is an analogue of Substance P that acts on the neurokinin 1 receptor (NK1R) in rat brain, similarly to Substance P but with a significantly extended duration of action. T...

Compounds

PF-04859989 HCl

T28368

Synonym: PF 04859989,PF04859989,PF-04859989HCl,PF-04859989

Target: Others

Flibanserin

T4297

Synonym: BIMT-17BS,Girosa,BIMT-17

Target: Dopamine Receptor, 5-HT Receptor

LY262691

T27936

Synonym: LY 262691,LY-262691

[Glp5,(Me)Phe8,Sar9] Substance P (5-11)

T76404

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00005	FGF-8a Protein, Human, Recombinant	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-06986	FGF-8b Protein, Human, Recombinant	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-02525	RGMA Protein, Human, Recombinant (His)	Human	HEK293 Cells
	RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein th...
TMPK-01030	LRRN1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Lrrn1 is required for the formation of MHB--loss of function leads to a loss of the morphological constriction and loss of Fgf8. Cells overexpressing Lrrn1 violate the boundary and result in a loss of cell restriction be...
TMPJ-00017	GNRH2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Progonadoliberin-2, also known as Progonadoliberin II and GNRH2, belongs to the gonadotropin-releasing hormone family. GNRH2 is specially expressed in midbrain, at significantly higher levels outside the brain (up to 30-...