| T22736 |
DMeOB
|
40252-74-2
|
98%
|
|
|
DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.
|
| T15619 |
JNJ-46778212
|
1363281-27-9
|
98%
|
|
|
JNJ-46778212 (VU 0409551) is a selective and potent mGlu5 allosteric modulator (EC50: 260 nM) for the study of neurodissection.
|
| T3477 |
E4CPG
|
170846-89-6
|
98%
|
|
|
E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.
|
| T3957 |
Farampator
|
211735-76-1
|
98%
|
|
|
Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.
|
| T9011 |
VU0155094
|
731006-86-3
|
98%
|
|
|
VU0155094 (ML 397) is a positive allosteric modulator with differential activity at the various group III mGluRs.
|
| T20191 |
(-)-Camphoric acid
|
560-09-8
|
98%
|
|
|
(-)-Camphoric acid (L-Camphoric acid) is a less active enantiomer of Camphoric acid which induces GluR expression.
|
| T20571 |
Cis-PDA
|
46026-75-9
|
98%
|
|
|
cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.
|
| T22840 |
HexylHIBO
|
334887-43-3
|
98%
|
|
|
HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats.
|
| T3479 |
(RS)-MCPG
|
146669-29-6
|
98%
|
|
|
(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.
|
| T22711 |
DCB
|
6971-97-7
|
98%
|
|
|
DCB (3,3'-dichlorobenzaldazine) is an allosteric ligand for mGluR5 and shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB). DCB blocks the...
|
| T41301 |
L-Cysteinesulfinic acid monohydrate
|
207121-48-0
|
98%
|
|
|
L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mG...
|
| T13321 |
VU6005649
|
2137047-43-7
|
98%
|
|
|
VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).
|
| T22976 |
MFZ 10-7
|
1224431-15-5
|
98%
|
|
|
MFZ 10-7 is anegative allosteric modulator of the mGluR5.
|
| T4500 |
ADX88178
|
1235318-89-4
|
|
|
|
ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
|
| T6871 |
L-Glutamic acid monosodium salt
|
142-47-2
|
|
|
|
L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.
|
| T6022 |
LY404039
|
635318-11-5
|
|
|
|
LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
|
| T1443 |
Memantine hydrochloride
|
41100-52-1
|
|
|
|
Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparki...
|
| T7494 |
TCN238
|
125404-04-8
|
|
|
|
TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
|
| T13441 |
(R)-ADX-47273
|
851881-59-9
|
|
|
|
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).
|
| T23259 |
(RS)-3-Hydroxyphenylglycine
|
31932-87-3
|
|
|
|
PI-linked metabotropic glutamate receptors agonist
|
