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PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.
Cat. No. 製品名 CAS No. Purity Chemical Structure
TN1271 Scutellarein tetramethyl ether 1168-42-9 98%
Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is extracted from Siam weeds and exhibits anti-inflammatory activity through NF-κB pathway.
TN3831 (-)-Denudatin B 87402-88-8 98%
(-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoi...
T14007 PAF-AN-1 115621-84-6 98%
PAF-AN-1 is a novel potent platelet-activating factor receptor (PAF) antagonist involved in the study of anaphylactic death.
T17178 Tulopafant 116289-53-3 98%
Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.
TN2322 Yangambin 13060-14-5 98.02%
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peri...
T2751 Ginkgolide B 15291-77-7 99.39%
Ginkgolide B (BN-52021) is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
T10159 48740 RP 93363-11-2 99.4%
48740 RP (RP 55779) is an antagonist of platelet-activating factor.
TN1643 Ferulamide 61012-31-5 99.45%
Ferulamide (4-Hydroxy-3-methoxycinnamide), a Ferulic acid derivative, shows potent inhibitory activity against arachidonic acid-induced platelet aggregation.
T6242 Rupatadine Fumarate 182349-12-8 99.64%
Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
TN2329 Zingiberen newsaponin 91653-50-8 99.75%
Zingiberen newsaponin is a steroidal saponin from Dioscorea zingiberensis.
TN4660 Niranthin 50656-77-4 99.8%
Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitiv...
TN4181 Hancinone C 111843-10-8 98%
Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
TN3520 Bisdethiobis(methylthio)gliotoxin 74149-38-5 98%
Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
TN4088 Futoenone 19913-01-0 98%
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate...
TN1815 Kadsulignan L 163660-06-8 98%
Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC5...
TN5045 Spiradine F 21040-64-2 98%
Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
TN3443 Aristolactam AII 53948-07-5 98%
Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
TN3979 Epiyangambin 24192-64-1 98%
Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lac...
TN4367 Kadsurin A 99340-07-5 98%
Kadsurin A has anti-platelet activating factor activities.
TN3740 Cyclocommunol 145643-96-5 98%
Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong in...
Scutellarein tetramethyl ether
TN1271
Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is extracted from Siam weeds and exhibits anti-inflammatory activity through NF-κB pathway.
(-)-Denudatin B
TN3831
(-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoi...
PAF-AN-1
T14007
PAF-AN-1 is a novel potent platelet-activating factor receptor (PAF) antagonist involved in the study of anaphylactic death.
Tulopafant
T17178
Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.
Yangambin
TN2322
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peri...
Ginkgolide B
T2751
Ginkgolide B (BN-52021) is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
48740 RP
T10159
48740 RP (RP 55779) is an antagonist of platelet-activating factor.
Ferulamide
TN1643
Ferulamide (4-Hydroxy-3-methoxycinnamide), a Ferulic acid derivative, shows potent inhibitory activity against arachidonic acid-induced platelet aggregation.
Rupatadine Fumarate
T6242
Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
Zingiberen newsaponin
TN2329
Zingiberen newsaponin is a steroidal saponin from Dioscorea zingiberensis.
Niranthin
TN4660
Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitiv...
Hancinone C
TN4181
Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
Bisdethiobis(methylthio)gliotoxin
TN3520
Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
Futoenone
TN4088
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate...
Kadsulignan L
TN1815
Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC5...
Spiradine F
TN5045
Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
Aristolactam AII
TN3443
Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
Epiyangambin
TN3979
Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lac...
Kadsurin A
TN4367
Kadsurin A has anti-platelet activating factor activities.
Cyclocommunol
TN3740
Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong in...
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