TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	製品名	CAS No.	Purity	Chemical Structure
TN1507	Clematichinenoside AR	761425-93-8	98%
TN1507	Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associate...
T37445	Etanercept	185243-69-0	98%
T37445	Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β ...
T2S1040	Jolkinolide B	37905-08-1	98%
T2S1040	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
TN2079	(-)-Pinoresinol	81446-29-9	98%
TN2079	(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb.
T1813	VGX-1027	6501-72-0	98%
T1813	VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.
T77484	Atibuclimab	2417175-94-9	98%	Atibuclimab
T77484	Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region. Atibuclimab can be used to treat ...			Atibuclimab
T77138	Ragifilimab	2207590-51-8	98%	Ragifilimab
T77138	Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting glucocorticoid-induced TNFR-associated protein (GITR). Ragifilimab can be used in the study...			Ragifilimab
T77129	Belantamab	2061894-48-0	98%	Belantamab
T77129	Belantamab (GSK2857914) is a humanized IgG1 monoclonal antibody against BCMA (TNFRSF17). Belantamab is a naked antibody to Belantamab mafodotin and can be used t...			Belantamab
T76957	Belimumab	356547-88-1	98%
T76957	Belimumab(LymphoStat B) is a human IgG1λ monoclonal antibody that inhibits B-cell activating factor (BAFF).Belimumab is used in the study of fatigue and in the t...
T76787	Conatumumab	896731-82-1	98%	Conatumumab
T76787	Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 (DR5, TRAILR2) at Kd 1 nM for long DR5 and Kd 0.8 nM for short DR5. Conat...			Conatumumab
T76718	Brentuximab	2088770-90-3	98%
T76718	Brentuximab is a chimeric antibody targeting CD30 and is a naked antibody to Brentuximab vedotin.Brentuximab has antitumor activity and may be used to study rela...
T76711	Golimumab	476181-74-5	98%
T76711	Golimumab (CNTO-148) is a potent humanized anti-TNFα IgG1κ monoclonal antibody.Golimumab has anti-inflammatory and anticancer activity, inhibits the production o...
T76706	Varlilumab	1393344-72-3	98%	Varlilumab
T76706	Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.			Varlilumab
T76705	Utomilumab	1417318-27-4	98%
T76705	Utomilumab (PF 05082566) is a humanized IgG2 antibody targeting the T-cell co-stimulatory receptor 4-1BB/CD137 and a 4-1BB/CD137 agonist.Utomilumab has antitumor...
T14848	C 87	332420-90-3	98%
T14848	C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-...
TN7235	4-methoxylonchocarpin	51589-67-4	98%
TN7235	4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TN...
TN2539	1beta-Hydroxyalantolactone	68776-47-6	98%
TN2539	1beta-Hydroxyalantolactone is a small molecular compound isolated from the flower head of the medicinal plant giant British flower, which can inhibit the express...
TN1403	Arjunolic acid	465-00-9	98%
TN1403	Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
TC0036	Compound Lup-20(29)-en-3-yl acetate	TC0036	98%
TC0036	Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.
T12985	SPD304 dihydrochloride	1049741-03-8	98%
T12985	SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.