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AUTACs

Autophagy-targeting chimeras (AUTACs) contain a guanine tag and a specific binder of an intracellular target of interest. AUTACs both downregulated cytosolic proteins and promoted targeted mitochondrial turnover via mitophagy. Mitochondria-targeted AUTAC (mito-AUTAC) treatment significantly improved mitochondrial activities in Down syndrome (DS)-derived fibroblast cells. This AUTAC technology may hold promise as the first autophagy-inducing agent with cargo specificity.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T60015 TSPO ligand-2  1160640-95-8 99.05%
TSPO ligand-2 (Carbonic acid) is a ligand of AUTAC1 which contains a p-fluorobenzylguanine and a Fumagillol moiety.
T82632 Cys-C-cGMP 2241669-85-0 98%
Cys-C-cGMP serves as an autophagy tag for AUTACs (autophagy-targeting chimeras). It enhances K63-linked ubiquitination of mitochondria within HeLa cells [1].
T82413 FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 2241669-84-9 98%
FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 serves as a linker for AUTAC4, a compound comprising a p-fluorobenzylguanine (FBnG) unit and a phenylindole moiety....
T80928 TSPO ligand-3 2241669-89-4 98%
TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the subs...
T74025 AUTAC1 2241669-09-8 99.82%
AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to sy...
TSPO ligand-2 
T60015
TSPO ligand-2 (Carbonic acid) is a ligand of AUTAC1 which contains a p-fluorobenzylguanine and a Fumagillol moiety.
Cys-C-cGMP
T82632
Cys-C-cGMP serves as an autophagy tag for AUTACs (autophagy-targeting chimeras). It enhances K63-linked ubiquitination of mitochondria within HeLa cells [1].
FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2
T82413
FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 serves as a linker for AUTAC4, a compound comprising a p-fluorobenzylguanine (FBnG) unit and a phenylindole moiety....
TSPO ligand-3
T80928
TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the subs...
AUTAC1
T74025
AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to sy...