AUTACs

Autophagy-targeting chimeras (AUTACs) contain a guanine tag and a specific binder of an intracellular target of interest. AUTACs both downregulated cytosolic proteins and promoted targeted mitochondrial turnover via mitophagy. Mitochondria-targeted AUTAC (mito-AUTAC) treatment significantly improved mitochondrial activities in Down syndrome (DS)-derived fibroblast cells. This AUTAC technology may hold promise as the first autophagy-inducing agent with cargo specificity.

Cat. No.	製品名	CAS No.	Purity
T60015	TSPO ligand-2	1160640-95-8	99.05%
TSPO ligand-2 (Carbonic acid) is a ligand of AUTAC1 which contains a p-fluorobenzylguanine and a Fumagillol moiety.
T74025	AUTAC1	2241669-09-8	98%
AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to sy...
T82632	Cys-C-cGMP	2241669-85-0	98%
Cys-C-cGMP serves as an autophagy tag for AUTACs (autophagy-targeting chimeras). It enhances K63-linked ubiquitination of mitochondria within HeLa cells [1].
T82413	FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2	2241669-84-9	98%
FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 serves as a linker for AUTAC4, a compound comprising a p-fluorobenzylguanine (FBnG) unit and a phenylindole moiety....
T80928	TSPO ligand-3	2241669-89-4	98%
TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the subs...

Cat. No.

製品名

CAS No.

Purity

Chemical Structure

T60015

TSPO ligand-2

1160640-95-8

99.05%

TSPO ligand-2 (Carbonic acid) is a ligand of AUTAC1 which contains a p-fluorobenzylguanine and a Fumagillol moiety.

T74025

AUTAC1

2241669-09-8

98%

AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to sy...

T82632

Cys-C-cGMP

2241669-85-0

98%

Cys-C-cGMP serves as an autophagy tag for AUTACs (autophagy-targeting chimeras). It enhances K63-linked ubiquitination of mitochondria within HeLa cells [1].

T82413

FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2

2241669-84-9

98%

FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 serves as a linker for AUTAC4, a compound comprising a p-fluorobenzylguanine (FBnG) unit and a phenylindole moiety....

T80928

TSPO ligand-3

2241669-89-4

98%

TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the subs...