LYTACs

Lysosomal-Targeting Chimeras (LYTACs) can target extracellular proteins. LYTACs and MoDE-As tether extracellular or membrane-bound POIs to a recycling receptor, which facilitates internalization and subsequent lysosomal degradation. LYTACs utilize the cation-independent mannose-6-phosphate receptor CI-M6PR, a recycling membrane protein that binds POIs labeled with an MP6n tag. GalNAc-LYTACs and MoDE-As utilize a GalNAC tag to recruit the asialoglycoprotein receptor (ASGPR), a liver-specific lysosomal targeting receptor, for tissue-specific degradation.

Cat. No.	製品名	CAS No.	Purity
T77945	TriGalNAc CBz	186613-57-0	98.13%
T77945	TriGalNAc CBz is a GalNAc derivative. As an ASGPR ligand, tri-GalNAc targets lysosomes in mRNA drug delivery and LYTAC studies.L-DABA hydrobromide.
T39370	Tri-GalNAc-COOH	1953146-81-0	99.13%
T39370	Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
T82537	D-MoDE-A (1)	2378837-67-1	98%
T82537	D-MoDE-A (1) is a bifunctional small molecule that facilitates extracellular protein degradation via the asialoglycoprotein receptor (ASGPR).
T81779	M-MoDE-A (2)	2378837-56-8	98%
T81779	M-MoDE-A (2) is a bifunctional small molecule that facilitates the degradation of extracellular proteins via the asialoglycoprotein receptor (ASGPR).
T80947	Tri-GalNAc-COOH (acetylation)		98%
T80947	Tri-GalNAc-COOH acetylation represents the acetylated derivative of tri-galactosamine (tri-GalNAc-COOH), utilized in the synthesis of lysosome targeting chimeras...
T80946	Tri-GalNAc-NHS ester	1953146-83-2	98%
T80946	Tri-GalNAc-NHS ester, a LYsosome TArgeting Chimera (LYTAC) and ligand for the asialoglycoprotein receptor (ASGPR), facilitates the degradation of extracellular p...
T77947	Tri-GalNAc(OAc)3 TFA	1159408-65-7	98%
T77947	Tri-GalNAc(OAc)3 TFA, a triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand, is utilized in the synthesis of GalNAc-lysosome-targeting chimera (GalNAc-LYTAC...
T77946	Tri-GalNAc(OAc)3	1159408-64-6	98%
T77946	Tri-GalNAc(OAc)3, a triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand, is utilized in the synthesis of GalNAc-lysosome targeting chimeras (LYTAC). These c...
T77941	Tri-GalNAc biotin		98%
T77941	Tri-GalNAc biotin, a small molecule lysosome targeting degrader, serves as a ligand for the asialoglycoprotein receptor (ASGPR). It promotes the uptake of NeutrA...
T77935	Tri-GalNAc(OAc)3-Perfluorophenyl		98%
T77935	Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl-modified triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand utilized in the synthesis of GalNAc-lys...