Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM against ErbB-2. It achieves covalent inactivation of ErbB-1 through modification of a cysteine residue within the enzyme's active site [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 383,500 |
50 mg | 約8-10 週間 | ¥ 500,500 |
100 mg | 約8-10 週間 | ¥ 643,000 |
説明 | 2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM against ErbB-2. It achieves covalent inactivation of ErbB-1 through modification of a cysteine residue within the enzyme's active site [1]. |
ターゲット&IC50 | ErbB2:45 μM |
In vitro | 2'-Thioadenosine (50 µM) exhibits no activity towards the receptor tyrosine kinases of FGF, PDGF, and insulin [1]. However, it causes the covalent inactivation of ErbB-1, which can be reversed by 1 mM Dithiothreitol [1]. |
別名 | PD157432 |
分子量 | 283.31 |
分子式 | C10H13N5O3S |
CAS No. | 136904-69-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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2′-Thioadenosine 136904-69-3 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR PD157432 Inhibitor inhibitor inhibit