Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 12,000 | |||
10 mg | 在庫あり | ¥ 20,500 | |||
25 mg | 在庫あり | ¥ 41,000 | |||
50 mg | 在庫あり | ¥ 68,500 | |||
100 mg | 在庫あり | ¥ 110,000 |
説明 | EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research. |
ターゲット&IC50 | EGFR (L858R/T790M):24 nM |
In vitro | EAI001 (50 μM) exhibits binding to EGFR T790M/C797S/V948R, situated deep within the EGFR near the ATP binding site and the C-helix. The inhibitory activity of EAI001 is attributed to its hydrophobic interactions with amino acids Ile759, Leu747, Leu788, Leu777, and Met766.[1] |
分子量 | 349.41 |
分子式 | C19H15N3O2S |
CAS No. | 892772-75-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (257.58 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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EAI001 892772-75-7 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR Inhibitor inhibitor inhibit