Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 53,500 |
5 mg | 約 5 days | ¥ 91,500 |
1 mL * 10 mM (in DMSO) | 約 5 days | ¥ 82,000 |
説明 | 3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM). |
ターゲット&IC50 | 5-HT2C receptor:1.8 μM (ki), 5-HT2C receptor:3.2 μM |
In vitro | The metabolite 3-Hydroxy agomelatine (S 21540) has a 10-fold lower affinity (Ki = 1.8 μM). Agomelatine, S 21517, and 3-Hydroxy agomelatine (0.1-100 μM) are antagonists at 5-HT2C receptors, with a rank order of efficacy as follows: S 21517>Agomelatine>3-Hydroxy agomelatine. |
In vivo | Increasing doses (1.25~40 mg/kg, i.p.) of 3-Hydroxy agomelatine does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat. |
分子量 | 259.3 |
分子式 | C15H17NO3 |
CAS No. | 166526-99-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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