Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Buspirone hydrochloride (Buspar) is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).
説明 | Buspirone hydrochloride (Buspar) is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD). |
In vitro | Buspirone, a clinically effective non-benzodiazepine anxiolytic drug, causes inhibition of firing of these neurons when given by intravenous (ED50 = 0.011 mg/kg, i.v.), intraperitoneal (ED50 = 0.088 mg/kg, i.p.), and intragastric (effective dose = 1.0-20.0 mg/kg, i.g.) injection. Buspirone also inhibits these cells when it is administered to the outside of recorded neurons by microiontophoresis. [1] Buspirone is eliminated primarily by oxidative metabolism, which produces several hydroxylated metabolites, including 5-hydroxy-buspirone and 1-pyrimidinylpiperazine. [2] |
別名 | Buspirone HCl, Narol, Buspar |
分子量 | 421.96 |
分子式 | C21H32ClN5O2 |
CAS No. | 33386-08-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 42.2 mg/mL (100 mM)
DMSO: 42.2 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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Buspirone hydrochloride 33386-08-2 GPCR/G Protein Neuroscience Dopamine Receptor 5-HT Receptor 5-HT1A receptor Inhibitor Reactive Oxygen Species Buspirone HCl Narol inhibit 5-hydroxytryptamine Receptor Serotonin Receptor depression Buspar Buspirone Hydrochloride anxiety Buspirone inhibitor