Powder: -20°C for 3 years | In solvent: -80°C for 1 year
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 9,500 | |||
50 mg | 在庫あり | ¥ 12,500 | |||
100 mg | 在庫あり | ¥ 17,500 | |||
200 mg | お問い合わせ | ¥ 25,500 |
説明 | 9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel. |
In vitro | In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50). Channel inhibition was voltage independent. The IC(50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5[1]. |
分子量 | 194.23 |
分子式 | C14H10O |
CAS No. | 484-17-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 19 mg/mL (97.82 mM), Sonication is recommended.
Ethanol: 9 mg/mL (46.34 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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9-Phenanthrol 484-17-3 Membrane transporter/Ion channel TRP/TRPV Channel ischemia-reperfusion injury inhibit TRPM4 NSC-50554 9Phenanthrol Inhibitor NSC 50554 TRP Channel 9-Hydroxyphenanthrene Transient receptor potential channels 9 Phenanthrol NSC50554 inhibitor