keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AF 12198 Acetate is a novel low molecular weight antagonist of IL-1
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 160,000 |
5 mg | 在庫あり | ¥ 337,500 |
10 mg | 在庫あり | ¥ 454,500 |
25 mg | 在庫あり | ¥ 677,000 |
50 mg | 在庫あり | ¥ 913,500 |
100 mg | 在庫あり | ¥ 1,230,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 893,000 |
説明 | AF 12198 Acetate is a novel low molecular weight antagonist of IL-1 |
ターゲット&IC50 | IL-8:25 nM |
In vitro | ?In vitro, AF12198 inhibits IL-1-induced IL-8 production by human dermal fibroblasts with a half-maximal inhibition concentration or IC50 of 25 nM and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression by endothelial cells with an IC50 of 9 nM[1]. |
In vivo | When given as an intravenous infusion to cynomolgus monkeys, AF12198 blocks ex vivo IL-1 induction of IL-6 and down modulates in vivo induction of IL-6.?This is the first small molecule to show IL-1 receptor antagonist activity in vivo[1].? |
別名 | AF 12198 Acetate (185413-30-3 Free base) |
分子量 | 1955.17 |
分子式 | C98H127N19O24 |
CAS No. | T21644L |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (30.69 mM)
You can also refer to dose conversion for different animals. 詳細
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AF 12198 Acetate T21644L Immunology/Inflammation IL Receptor AF 12198 Acetate (185413-30-3 Free base) AF-12198 Acetate AF12198 Acetate 185413-30-3 185413-30-3 Free base Inhibitor inhibitor inhibit