Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AP5 is a potent and selective agonist for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49 nM against the GPR40 receptor.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 555,500 |
50 mg | 約10-14 週間 | ¥ 730,000 |
100 mg | 約10-14 週間 | ¥ 987,000 |
説明 | AP5 is a potent and selective agonist for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49 nM against the GPR40 receptor. |
ターゲット&IC50 | FFA1/GPR40 receptor:(EC50)0.49±0.28 nM |
In vitro | In the GK rat oral glucose tolerance test (oGTT), oral administration of AP5 1 h before an oral dextrose challenge shows that AP5 significantly reduces blood glucose levels compared to the vehicle. AP5 is determined to be more efficacious in this model, demonstrating maximally efficacious glucose-lowering at a plasma concentration of 4.9 μM at 10 mg/kg. |
分子量 | 461.52 |
分子式 | C28H28FNO4 |
CAS No. | 1623194-37-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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AP5 1623194-37-5 Others AP-5 AP 5 Inhibitor inhibitor inhibit