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Search Results for " AP-5 "

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阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T8993L	BGC-20-1531 hydrochloride(1186532-61-5 free base)	BGC-20-1531 hydrochloride,GTPL3380 hydrochloride,AP-1531 hydrochloride	Prostaglandin Receptor
	BGC-20-1531 hydrochloride(1186532-61-5 free base) (GTPL3380 hydrochloride) is a EP4 antagonist for the treatment of acute migraine.		Prostaglandin Receptor
T13550	AP5		Others
	AP5 is a potent and selective agonist for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49 nM against the GPR40 receptor.		Others
T10930	D-AP5	D-APV,D-2-Amino-5-phosphonovaleric acid	NMDAR , iGluR
	D-AP5 (D-APV) is a NMDA receptor antagonist.		NMDAR , iGluR
T22733	DL-AP5		NMDAR
	DL-AP5 is the racemic form of a selective N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant effects.		NMDAR
T22909	L-AP5		Others
	L-AP5 is a NMDA antagonist.		Others
T23081	NPEC-caged-D-AP5		Others
	NPEC-caged-D-AP5 is a NMDA receptor antagonist.		Others
T22732	DL-AP5 Sodium salt		Others
	DL-AP5 Sodium salt is a NMDA receptor antagonist.		Others
T77570	AP-C2		PKA
	AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.		PKA
T60500	AP-C5		Parasite
	AP-C5 is a compound with selective inhibition of guanosine 3',5' cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), with a Pic50 value of 7.2 for cGMP, and can be used in the study of diarrheal diseases.		Parasite
T5416	T-5224		MMP
	T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors.		MMP
T26640	AP-521 (Free base)	AP-521,AP521,AP 521
	AP-521, a 5-HT1A receptor antagonist, is used potentially for the treatment of anxiety.
T82990	AP-C4
	AP-C4 is a selective inhibitor targeting guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), exhibiting a pIC50 value of 5.2. Conversely, AP-C3 does not inhibit cGKII-mediated anion secretion...
T82991	AP-C3
	AP-C3 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), exhibiting a pIC50 value of 6.3 and demonstrating only weak inhibition of cGKII-dependent anion secretion [1...
T82989	AP-C6
	AP-C6 is a potent inhibitor of guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), exhibiting a pIC50 of 6.5. It inhibits human cGKII activity in vitro in a concentration-dependent manner and...
T37969	12(S)-HpETE
	12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the sy...
T35943	15(S)-HpETE
	15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A4 [1] or reduced to 15(S)-HETE by ...

Compounds

BGC-20-1531 hydrochloride(1186532-61-5 free base)

T8993L

Synonym: BGC-20-1531 hydrochloride,GTPL3380 hydrochloride,AP-1531 hydrochloride

Target: Prostaglandin Receptor

Synonym: D-APV,D-2-Amino-5-phosphonovaleric acid

Synonym: AP-521,AP521,AP 521

カタログ番号	製品名	別名	ターゲット
TN1237	3-O-Methylgallic acid	3,4-Dihydroxy-5-methoxybenzoic acid	Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
	3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation ...		Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
T4700	1,3,5-Trihydroxy-4-prenylxanthone
	1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylch...

天然物製品

3-O-Methylgallic acid

TN1237

Synonym: 3,4-Dihydroxy-5-methoxybenzoic acid

Target: Apoptosis, NF-κB, OCT, DNA/RNA Synthesis, STAT

1,3,5-Trihydroxy-4-prenylxanthone

T4700

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02433	APE1/APEX1 Protein, Human, Recombinant (His)	Human	E. coli
	The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease, DNA 3' repair diest...
TMPY-02798	NEIL1 Protein, Human, Recombinant (His)	Human	E. coli
	NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed a...
TMPY-05308	CD45 Protein, Human, Recombinant (aa 1-529, His)	Human	HEK293 Cells
	CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5.
TMPY-02949	AP2 Gamma/TFAP2C Protein, Human, Recombinant (His)	Human	E. coli
	TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of imp...
TMPJ-00854	ETS1 Protein, Human, Recombinant (His)	Human	E. coli
	ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or ...
TMPY-05387	SLAMF7 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPY-05498	SR-BI/SCARB1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5.
TMPY-04318	GRIK2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar...
TMPY-05547	SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated	Human	HEK293 Cells
	SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPK-01363	SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...
TMPK-01357	SIRP alpha V5 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...