keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition to immune activation and antitumor activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 27,000 | |||
5 mg | 在庫あり | ¥ 75,000 | |||
10 mg | 在庫あり | ¥ 112,500 | |||
25 mg | 在庫あり | ¥ 183,500 | |||
50 mg | 在庫あり | ¥ 250,500 | |||
100 mg | 在庫あり | ¥ 340,000 |
説明 | AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition to immune activation and antitumor activity. |
In vitro | In vitro, AUNP-12 displayed equipotent antagonism toward PD-L1 and PD-L2 in the rescue of lymphocyte proliferation and effector functions. In human PBMC cells, AUNP-12 was also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition in vitro, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively. [1] |
In vivo | AUNP-12 acetate rescued the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively. AUNP-12 (6 hours) showed a Plasma protein binding of 93.9% with plasma stability of more than 60%. AUNP-12 exhibited a half-life of 90 minutes in mouse liver microsomes. In male Balb/c mice, AUNP-12 subcutaneous injection or intravenous injection as a concentration of 3 mg/kg for its PK study. As a result, AUNP-12 shows a low volume of distribution, and the peak plasma levels reach at 0.2-0.4 hours. The absolute bioavailability of AUNP-12 is about 77% in mice. [1] |
別名 | AUNP-12 acetate (1353563-85-5 Free base) |
分子量 | 3321.61 |
分子式 | C144H230N40O50 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AUNP-12 acetate Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 AUNP-12 acetate (1353563-85-5 Free base) AUNP12 acetate AUNP 12 acetate 1353563-85-5 Free base AUNP-12 Acetate AUNP12 Acetate AUNP 12 Acetate 1353563-85-5 Inhibitor inhibitor inhibit