Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sulfamethoxypyridazine (CL 13494) is a sulfanilamide antibacterial agent.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
50 mg | 在庫あり | ¥ 7,500 | |||
100 mg | 在庫あり | ¥ 11,000 | |||
200 mg | 在庫あり | ¥ 14,000 | |||
500 mg | 在庫あり | ¥ 22,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Sulfamethoxypyridazine (CL 13494) is a sulfanilamide antibacterial agent. |
In vitro | In goats, following intramuscular (im) and subcutaneous (sc) administration, Sulfamethoxypyridazine has half-lives of 11.0 h and 13.7 h with bioavailabilities of 68.6% and 58.7%, respectively. The distribution and elimination half-lives are 0.1 h and 6.28 h, while the steady-state volume of distribution and total body clearance rates are 0.39 ml/kg/min and 0.73 ml/kg/min, respectively. Preliminary studies in rats infected with Pneumocystis carinii demonstrated that Sulfamethoxypyridazine is very effective. It was also found that treatment of Pneumocystis carinii infection in rats with Sulfamethoxypyridazine (1 mg/kg) is as effective as sulfamethazole. In a mouse model, Sulfamethoxypyridazine effectively combats Pneumocystis carinii, with ED50s based on silver stain and Giemsa stain scoring of 0.08 mg/kg/day and 0.06 mg/kg/day, respectively. Treatments of 0.1 mg/kg/day or 0.3 mg/kg/day show more pronounced effects against Pneumocystis carinii in the mouse model than the 0.47 mg/kg/day dose. |
別名 | CL 13494 |
分子量 | 280.3 |
分子式 | C11H12N4O3S |
CAS No. | 80-35-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 52 mg/mL (185.5 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Sulfamethoxypyridazine 80-35-3 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation Microbiology/Virology Antibacterial Antibiotic PD-1/PD-L1 CL 13494 Bacterial inhibit CL-13494 Inhibitor CL13494 inhibitor