store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 13,500 | |||
5 mg | 在庫あり | ¥ 38,000 | |||
10 mg | 在庫あり | ¥ 56,000 | |||
25 mg | 在庫あり | ¥ 91,500 | |||
50 mg | 在庫あり | ¥ 137,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 45,000 |
ターゲット&IC50 | CDK9:4 nM (IC50) |
In vitro | Short-term administration of AZD4573 induced a swift, dose- and time-dependent reduction in cellular pSer2-RNAPII levels, which in turn activated caspase 3, leading to apoptosis across a wide spectrum of hematological cancer cell lines. Notably, caspase activation exhibited an EC50 of 13.7 nM in the acute myeloid leukemia model MV4-11. |
分子量 | 429.94 |
分子式 | C22H28ClN5O2 |
CAS No. | 2057509-72-3 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (290.74 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AZD4573 2057509-72-3 Cell Cycle/Checkpoint CDK inhibit Inhibitor AZD-4573 AZD 4573 Cyclin dependent kinase inhibitor