Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Acolbifene (SCH 57068) is a selective antagonist of estrogen receptors with IC50s of 2 nM and 0.4 nM for estradiol-induced transcriptional activity of ERα and ERβ. Acolbifene shows an anticarcinogenic property.
パッケージサイズ | 在庫状況 | 単価(税別) | |
---|---|---|---|
1 mg | 在庫あり | ¥ 17,500 | |
5 mg | 在庫あり | ¥ 41,000 | |
50 mg | 約6-8 週間 | お問い合わせ | |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 46,000 |
説明 | Acolbifene (SCH 57068) is a selective antagonist of estrogen receptors with IC50s of 2 nM and 0.4 nM for estradiol-induced transcriptional activity of ERα and ERβ. Acolbifene shows an anticarcinogenic property. |
ターゲット&IC50 | ERβ:0.4 nM (IC50, E2-induced transcriptional activity), ERα:2 nM (IC50, E2-induced transcriptional activity) |
In vitro | Acolbifene supports the involvement of the clearance-related receptors in its hypocholesterolemic action without affecting pathways of cholesterol synthesis[2]. Acolbifene inhibits estradiol-stimulated cell proliferation in human breast cancer cancer cells including ZR-75-1, MCF-7 and T-47D[4]. |
In vivo | In female Sprague-Dawley rats, Acolbifene (2.5 mg/kg; gavage) reduces food intake, strongly decreases cholesterolemia and prevents tumor growth. Acolbifene reduces food intake (16%) and weight gain (45%, mainly fat)[2]. |
別名 | EM-652, SCH 57068 |
分子量 | 457.56 |
分子式 | C29H31NO4 |
CAS No. | 182167-02-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (87.4 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Acolbifene 182167-02-8 Endocrinology/Hormones Estrogen Receptor/ERR EM-652 SCH 57068 SCH-57068 EM 652 SCH57068 EM652 Inhibitor inhibitor inhibit