keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alamandine TFA , a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine TFA targets to protect the kidney and heart through anti-hypertensive actions[1][2].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 13,000 | |||
2 mg | 在庫あり | ¥ 18,000 | |||
5 mg | 在庫あり | ¥ 26,000 | |||
10 mg | 在庫あり | ¥ 41,000 | |||
25 mg | 在庫あり | ¥ 81,000 | |||
50 mg | 在庫あり | ¥ 122,000 | |||
100 mg | 在庫あり | ¥ 176,500 | |||
500 mg | 在庫あり | ¥ 363,000 |
説明 | Alamandine TFA , a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine TFA targets to protect the kidney and heart through anti-hypertensive actions[1][2]. |
In vitro | Alamandine TFA is generated by catalysis of Ang A via ACE2 or directly from Angiotensin 1-7 (Ang-(1-7)). Derived from angiotensin II (Ang II) by Ang II-converting enzyme 2 (ACE2), it shows vasodilating (thus protective) properties. Ang (1-7) can be decarboxylated to a peptide called Alamandine TFA. Alamandine TFA is also an endogenous peptide identified in human blood[1]. Alamandine TFA elevates cAMP concentration in primary endothelial and mesangial cells, also suggesting Gs coupling[2]. Alamandine TFA decreases secretion, expression, and blood levels of leptin. Alamandine TFA induced expression of iNOS and plasminogen activator inhibitor-1 (PAI-1) in adipose tissue and isolated adipocytes[2]. |
In vivo | Alamandine TFA (0.15 ?μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension and impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide[3]. heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide[3]. |
分子量 | 969.02 |
分子式 | C42H63F3N12O11 |
CAS No. | T37496L |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Alamandine TFA T37496L Endocrinology/Hormones RAAS Inhibitor inhibitor inhibit