Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 15,000 | |||
5 mg | 在庫あり | ¥ 36,500 | |||
10 mg | 在庫あり | ¥ 49,000 | |||
25 mg | 在庫あり | ¥ 82,500 | |||
50 mg | 在庫あり | ¥ 122,500 | |||
100 mg | 在庫あり | ¥ 174,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 54,500 |
説明 | Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation. |
In vitro | OPHIOPOGONIN D(OP-D) significantly inhibited Ang II induced NF-κB nuclear translocation, IκBα down-regulation and activation of pro-inflammatory cytokines (TNF-α, IL-6 and VCAM-1) by increasing the expression of CYP2J2/EETs and PPARα in HUVECs.?Furthermore, treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-κB nuclear translocation, increased IκBα expression and decreased inflammation factor level.?Finally, the activation of NF-κB nuclear translocation induced by Ang II was also markedly suppressed by fenofibrate.?Co-incubation with 6-(2-proparglyloxyphenyl) hexanoic acid (PPOH) and PPARα inhibitor GW6471 before drug treatment abolished the endothelium protective effects of OP-D.?Suggest that OP-D has the endothelial protective effect through activation of CYP2J and increasing EETs, and PPARα involves in this process. |
分子量 | 855.02 |
分子式 | C44H70O16 |
CAS No. | 945619-74-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (35.09 mM)
You can also refer to dose conversion for different animals. 詳細
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OPHIOPOGONIN D 945619-74-9 DNA Damage/DNA Repair Endocrinology/Hormones Membrane transporter/Ion channel Metabolism NF-Κb PPAR NF-κB Calcium Channel RAAS Nuclear factor-κB Ca channels Nuclear factor-kappaB Ca2+ channels inhibit Inhibitor Peroxisome proliferator-activated receptors inhibitor