store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 nM for APJ.Apelin-13 has vasodilatory and antihypertensive activity and can be used to study type 2 diabetic syndrome. Apelin-13 has vasodilatory and antihypertensive activities and can be used to study type 2 diabetes syndrome.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 34,500 | |||
10 mg | 在庫あり | ¥ 59,000 | |||
25 mg | 在庫あり | ¥ 106,500 | |||
50 mg | 在庫あり | ¥ 159,500 |
説明 | Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 nM for APJ.Apelin-13 has vasodilatory and antihypertensive activity and can be used to study type 2 diabetic syndrome. Apelin-13 has vasodilatory and antihypertensive activities and can be used to study type 2 diabetes syndrome. |
ターゲット&IC50 | APJ:0.37 nM |
In vivo |
Administered intraperitoneally at a daily dosage of 200 µg/kg for 4 weeks, Apelin-13 improves cardiac function, insulin resistance, and lipid metabolism. It significantly decreases serum levels of TNF-α and leptin, induces the expression of Apelin-12 in serum, and markedly elevates levels of GLUT4 and p-AMPKα2[2]. When delivered via intracerebroventricular injection at single dosages of 10 and 100 μM, Apelin-13 increases the spontaneous discharges in the majority of pallidal neurons[3]. |
分子量 | 1550.83 |
分子式 | C69H111N23O16S |
CAS No. | 217082-58-1 |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (32.24 mM), Sonication is recommended.
DMSO: 50 mg/mL (32.24 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Apelin-13 217082-58-1 inhibit Inhibitor Apelin Receptor (APJ) nervous systems antihypertensive metabolic syndrome Apelin13 diabetes Goto-Kakizaki rat insulin resistance pallidal neurons lipid Apelin 13 Wistar rat vasodilatory inhibitor