Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication. This compound demonstrates high selectivity, distinguishing effectively between other serine/cysteine proteases. Additionally, BI-1230 exhibits favorable pharmacokinetic (PK) properties[1].
説明 | BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication. This compound demonstrates high selectivity, distinguishing effectively between other serine/cysteine proteases. Additionally, BI-1230 exhibits favorable pharmacokinetic (PK) properties[1]. |
ターゲット&IC50 | HCV NS3 protease:6.7 nM |
In vitro | BI-1230 demonstrates potent activity in biochemical and cellular assays. With a 60-minute incubation, it exhibits an IC50 value of 6.7 nM in an enzymatic assay[1]. Over 72 hours, BI-1230 shows EC50 values of 4.6 nM and <1.8 nM in a cell-based HCVPV RNA replication luciferase reporter assay with genotype backgrounds 1a and 1b, respectively, in Huh7 cells. |
分子量 | 816.96 |
分子式 | C42H52N6O9S |
CAS No. | 849022-32-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BI-1230 849022-32-8 Microbiology/Virology Proteases/Proteasome HCV Protease BI1230 BI 1230 Inhibitor inhibitor inhibit