Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS 193885 is a selective and competitive neuropeptide Y(1) receptor antagonist with affinity of 3.3 nM.
説明 | BMS 193885 is a selective and competitive neuropeptide Y(1) receptor antagonist with affinity of 3.3 nM. |
In vitro | BMS 193885 increases the Kd of [(125)I]PeptideYY from 0.35 nM to 0.65 nM without changing the Bmax (0.16 pmol/mg of protein) in SK-N-MC cells that endogenously express the neuropeptide Y(1) receptor[1]. BMS 193885 is a full antagonist with an apparent Kb of 4.5 nM measured by reversal of forskolin-stimulated inhibition of cAMP production by neuropeptide Y[1]. |
In vivo | BMS 193885 (10 mg/kg; i.p.) reduces one-hour neuropeptide Y-induced food intake in satiated rats, as well as spontaneous overnight food consumption. Chronic administration of BMS 193885 (10 mg/kg) i.p. for 44 days significantly reduces food intake and the rate of body weight gain compared to vehicle treated control without developing tolerance or affecting water intake[1]. |
別名 | BMS193885 |
分子量 | 680.79 |
分子式 | C36H48N4O9 |
CAS No. | 679839-66-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: <13.62mg/ml
DMSO: 63mg/mL (92.5mM)
You can also refer to dose conversion for different animals. 詳細
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BMS 193885 679839-66-8 GPCR/G Protein Neuroscience Neuropeptide Y Receptor BMS193885 BMS-193885 Inhibitor inhibitor inhibit