Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM).
説明 | MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM). |
ターゲット&IC50 | Y5 receptor:1.6 nM (Ki) |
In vitro | MK-0557 has a Ki=1.3 nM at the human NPY5R, with similar affinities at rhesus, mouse, and rat NPY5R. MK-0557 has no significant binding to the human NPY1R, NPY2R, NPY4R, or mouse NPY6R at concentrations of 10 μM [2]. |
In vivo | MK-0557 counteracts the NPY5R-selective agonist's influence on body-weight gain and hyperphagia in C57BL/6J mice, also markedly reducing body-weight gain in diet-induced obese (DIO) mice. A 40% reduction in body-weight gain is achieved by day 35 in lean mice shifted from regular chow to a medium high-fat diet (4.2 kcal/g), following treatment with MK-0557 at a dosage of 30 mg/kg PO QD[2]. |
分子量 | 406.41 |
分子式 | C22H19FN4O3 |
CAS No. | 328232-95-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (61.52 mM)
You can also refer to dose conversion for different animals. 詳細
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MK-0557 328232-95-7 GPCR/G Protein Neuroscience Neuropeptide Y Receptor MK0557 MK 0557 inhibit Inhibitor NPY receptor inhibitor