Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-plant growth and shows germination
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 41,000 | |||
2 mg | 在庫あり | ¥ 62,000 | |||
5 mg | 在庫あり | ¥ 104,500 | |||
10 mg | 在庫あり | ¥ 154,500 | |||
25 mg | 在庫あり | ¥ 243,500 | |||
50 mg | 在庫あり | お問い合わせ |
説明 | Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-plant growth and shows germination |
In vivo | Batatasin III may impose a lethal effect on the aquatic fauna in small streams. The maximum concentration of Batatasin III found was 1.06 mg l(-1). The proportion of dead yolk sac alevins increased significantly (P < 0.001) with increasing concentrations of Batatasin III and time of exposure. After 24 hr, EC50 was 10 mg l(-1). It was 2 mg l(-1) after 48 hr. The effect of phenol was negligible, indicating a specific phytotoxic effect of the bibenzyl structure of Batatasin III. The proportion of mobile D. magna became significantly smaller (P < 0.001) with increasing concentrations of Batatasin III, with decreasing pH, and with increasing exposure time. EC50 varied between 7 and 17 mg l(-1) at pH 5.5 and 7.0, respectively. After 24 hr EC50 decreased and was 2.5 at pH 5.5 and 12 mg l(-1) at pH 7.0. The levels of Batatasin III found in the field samples were below the lowest EC50 in acute toxicity tests[1]. Batatasin III significantly suppresses mesenchymal transition indicated by the decrease of N-cadherin and Vimentin and up-regulation of E-cadherin[1]. Batatasin III (25-100 μM; 48 h) exhibits anti-proliferative activity in H460 cells. Batatasin III at concentrations lower than 100 μM has no cytotoxic effects[2]. |
植物由来 |
分子量 | 244.29 |
分子式 | C15H16O3 |
CAS No. | 56684-87-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Batatasin III 56684-87-8 Angiogenesis Cytoskeletal Signaling Others PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors Akt FAK Focal adhesion kinase Inhibitor inhibit PTK2 protein tyrosine kinase 2 PKB PTK2 Protein kinase B inhibitor