Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
ターゲット&IC50 | L-selectin:86 μM, P-selectin:20 μM, Eselectin:88 μM |
In vitro | Bimosiamose (TBC-1269) effectively inhibits neutrophil recruitment to inflammation sites by obstructing the initial rolling phase of recruitment, without exhibiting cytotoxic effects on neutrophils. |
別名 | TBC-1269 |
分子量 | 862.91 |
分子式 | C46H54O16 |
CAS No. | 187269-40-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
0.1 M NaOH: 25 mg/mL (28.97 mM), when pH is adjusted to 10 with NaOH. Sonication is recommended.
DMSO: 125 mg/mL (144.86 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Bimosiamose 187269-40-5 Cytoskeletal Signaling Integrin TBC1269 TBC 1269 TBC-1269 Inhibitor inhibitor inhibit