Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx.
説明 | Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. |
ターゲット&IC50 | PLA2:7 μM |
In vitro | Bromoenol lactone inhibits exocytosis when stimulated using a Ca2+ ionophore A23187, which passively transports Ca2+ down a concentration gradient and also in permeabilized mast cells where Ca2+ entry is no longer relevant. In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca2+ entry is critical for exocytosis. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca2+ signaling, both the release from internal stores and sustained elevation due to Ca2+ influx [1]. |
別名 | (6E)-Bromoenol lactone |
分子量 | 317.18 |
分子式 | C16H13BrO2 |
CAS No. | 88070-98-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Bromoenol lactone 88070-98-8 Metabolism Phospholipase (6E)-Bromoenol lactone Inhibitor inhibitor inhibit