Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM. PACOCF3 alters Ca 2+ signaling in renal tubular cells [1] [2].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 13,000 | |||
25 mg | 在庫あり | ¥ 22,500 | |||
50 mg | 在庫あり | ¥ 38,500 | |||
100 mg | 在庫あり | ¥ 62,500 | |||
200 mg | 在庫あり | ¥ 91,000 |
説明 | PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM. PACOCF3 alters Ca 2+ signaling in renal tubular cells [1] [2]. |
In vitro | PACOCF3 does not affect basal cytosolic free calcium concentrations ([Ca2+]i) at 20 μM, but a dosage between 50-250 μM triggers an increase in [Ca2+]i through the stimulation of extracellular Ca2+ entry, which can be partially inhibited by 50 μM La3+[2]. This PACOCF3-induced effect is negated when extracellular Ca2+ is removed. At a concentration of 10 μM, PACOCF3 amplifies the peak and the area under the curve of the [Ca2+]i surge elicited by 10 μM ATP and 1 μM bradykinin, by enhancing extracellular Ca2+ influx without altering internal Ca2+ release[2]. |
別名 | 1,1,1-trifluoroheptadecan-2-one, Palmityltrifluoromethylketone |
分子量 | 308.42 |
分子式 | C17H31F3O |
CAS No. | 141022-99-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.5 mg/mL (102.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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PACOCF3 141022-99-3 Metabolism Phospholipase 1,1,1-trifluoroheptadecan-2-one Palmityltrifluoromethylketone PACOCF-3 Palmityltrifluoromethylketone PACOCF 3 Inhibitor inhibitor inhibit