store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Butyrolactone I (Olomoucin) is an ATP-competitive inhibitor of CDK and cdc2 kinase family. Butyrolactone I shows antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 34,000 | |||
5 mg | 在庫あり | ¥ 102,500 | |||
10 mg | 在庫あり | ¥ 148,500 | |||
25 mg | 在庫あり | お問い合わせ | |||
50 mg | 在庫あり | お問い合わせ |
説明 | Butyrolactone I (Olomoucin) is an ATP-competitive inhibitor of CDK and cdc2 kinase family. Butyrolactone I shows antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines. |
In vitro | Butyrolactone I (70 and 100 μM) increases the percentage of DU145 cells in the 4C phase of the cell cycle. Butyrolactone I increases the amount of cyclin B1 positive cells in the 4C phase on day 1 and returns to normal by day 3. Butyrolactone I inhibits Cdc2 of unsynchronized cultured prostate cancer cells and interrupts the cell cycle progression toward cell division. The Butyrolactone I inhibition of Cdc2 led to the accumulation of cells in the 4C phase without mitosis resulting in an accumulation of cyclin B1[3]. |
別名 | Olomoucin |
分子量 | 424.44 |
分子式 | C24H24O7 |
CAS No. | 87414-49-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Butyrolactone I 87414-49-1 Cell Cycle/Checkpoint CDK Olomoucin Inhibitor inhibitor inhibit