Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 18,500 | |||
5 mg | 在庫あり | ¥ 43,500 | |||
10 mg | 在庫あり | ¥ 64,000 | |||
25 mg | 在庫あり | ¥ 110,000 | |||
50 mg | 在庫あり | ¥ 157,500 | |||
100 mg | 在庫あり | ¥ 229,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 45,500 |
説明 | CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells. |
ターゲット&IC50 | CDK8:14 nM(Ki), GSK-3α:13 nM(ki), GSK-3β:4 nM(ki), PCKθ:109 nM(ki), MV-4-11 cells:0.36 μM(GI50) |
In vitro | CDK8-IN-12 (0.36, 0.72 μM ; 2 h) significantly reduced the phosphorylation of STAT1 serine 727.[1] |
In vivo | CDK8-IN-12 (intravenous administration ; 5 mg/kg in rats ; 2 mg/kg in mice) had a T1/2 of 0.9 h and 0.34 h in rats and mice, respectively.[1] |
分子量 | 381.86 |
分子式 | C21H20ClN3O2 |
CAS No. | 2613307-67-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (72.02 mM)
You can also refer to dose conversion for different animals. 詳細
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CDK8-IN-12 2613307-67-6 Cell Cycle/Checkpoint PI3K/Akt/mTOR signaling Stem Cells GSK-3 CDK CDK8IN12 Inhibitor inhibitor inhibit