Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion.
説明 | CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion. |
In vitro | CDDO-3P-Im (30 nM) induces differentiation of U937 cells. In RAW264.7 cells, CDDO-3P-Im suppresses NO production (IC50 = 4.3 nM)[1]. |
In vivo | CDDO-3P-Im reduces the size and the severity of the lung tumors in mouse lung cancer models. In A/J mice, CDDO-3P-Im (50-200 mg/kg; diet) decreases the number, size, and severity of tumors. CDDO-3P-Im significantly elevates heme oxygenase-1 and quinone reductase mRNA and protein levels in various mouse tissues[1]. |
分子量 | 618.81 |
分子式 | C39H46N4O3 |
CAS No. | 1883650-95-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225 mg/mL (363.6 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CDDO-3P-Im 1883650-95-0 Apoptosis Necroptosis CDDO 3P Im CDDO3PIm Inhibitor inhibitor inhibit